Heteroalkyl biphenyl antagonists of prostaglandin D2 receptors

A compound represented by the structure of Formula (I), or a pharmaceutically acceptable salt thereof:

• wherein,
• Q is tetrazolyl, or —C(═O)—Q1;
• Q1 is —OH, —ORA, —NHSO2R12, —N(R13)2, —NH—OH, or —NH—CN;
• RA is H or C1-C6alkyl;
• Y is —O—, —S—, —S(═O)—, or —S(═O)2—;
• each R1 is independently selected from H, F, and C1-C4alkyl;
• each of R2, R3, R4, R5, R6, R7, R8 and R9 is independently H, halogen, —CN, —NO2, —OH, —OR12, —SR12, —S(═O)R12, —S(═O)2R12, —N(R13)S(═O)2R12, —S(═O)2N(R13)2, —C(═O)R12, —OC(═O)R12, —CO2R13, —OCO2R13, —N(R13)2, —NHCH2CO2R13, —OCH2CO2R13, —SCH2CO2R13, —C(═O)N(R13)2, —OC(═O)N(R13)2, —NR13C(═O)N(R13)2, —NR13 ,2C(═O)R —NR13—C1-C4alkyl—C(═O)R12, —NR13C(═O)OR12, C1-C6alkyl, C1-C6fluoroalkyl, C1-C6fluoroalkoxy, C1-C6alkoxy, C1-C6heteroalkyl, a substituted or unsubstituted C3-C10ocycloalkyl, a substituted or unsubstituted C2-C10heterocycloalkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted heteroaryl, —C1-C4alkylene-(substituted or unsubstituted C3-C10cycloalkyl), —C1-C4alkylene—(substituted or unsubstituted C2-C10oheterocycloalkyl), 13 C1-C4alkylene-(substituted or unsubstituted aryl), or —C1-C4alkylene-(substituted or unsubstituted heteroaryl);
• each R10 is H;
• R11 is a substituted or unsubstituted C1-C6alkyl, C1-C6haloalkyl, C1-C6heteroalkyl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted heterocycloalkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted heteroaryl, —C1-C4alkylene—(substituted or unsubstituted C3-C10cycloalkyl), —C1-C4alkylene-(substituted or unsubstituted C2-C10heterocycloalkyl), —C1-C4alkylene—(substituted or unsubstituted aryl), —C1-C4alkylene—(substituted or unsubstituted heteroaryl), —C1—C6alkylene—O—R17, —C1-C6alkylene—S—R17, —C1-C6alkylene—S(═O )—R17, —C1-C6alkylene—S(═O)2-R17, —C1-C6alkylene—N(R17)2, —C_-C6alkylene—C(═O)—R17, —C1-C6alkylene—C(═O)—R17- , —C1- C6 alkylene—OC(═O)—R17, —C1-C6alkylene—NR17C(═O)—R17, —C1-C6alkylene—C(═O)N(R17)2, —C(═O)R12, —CO2R12, or —C(═O)N(R13)2;
• each R17 is independently selected from H, C1-C6alkyl, C1-C6heteroalkyl, C1-C6haloalkyl, a substituted or unsubstituted C3-C10cycloalkyl, a substituted or unsubstituted C3C10 heterocycloalkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted benzyl, and a substituted or unsubstituted heteroaryl;
• or two R17 groups attached to the same N atom are taken together with the N atom to which they are attached to form a substituted or unsubstituted C2-C10heterocycloalkyl;
• R12is C1-C6alkyl ,C1-C6 fluoroalkyl, a substituted or unsubstituted C3-C10cycloalkyl, C1-C6heteroalkyl, C1-C6fluoroalkyl, a substituted or unsubstituted C3-C1ocycloalkyl, a substituted or unsubstituted C2-C10heterocycloalkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted benzyl, a substituted or unsubstituted heteroaryl, —C1-C4alkylene-(substituted or unsubstituted C3-C10cycloalkyl), —C1-C4alkylene-(substituted or unsubstituted C2-C10heterocycloalkyl), —C1-C4alkylene-(substituted or unsubstituted aryl), or —C1-C4alkylene-(substituted or unsubstituted heteroaryl);
• each R13 is independently selected from H, C1-C6alkyl, C1-C6heteroalkyl, C1-C6fluoroalkyl, a substituted or unsubstituted C3-C10cycloalkyl, a substituted or unsubstituted C2-C10 heterocycloalkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted benzyl, a substituted or unsubstituted heteroaryl, —C1-C4alkylene-(substituted or unsubstituted C3-C10cycloalkyl), —C1-C4alkylene-(substituted or unsubstituted C2-C10heterocycloalkyl), —C1-C4alkylene-(substituted or unsubstituted aryl), and —C1-C4alkylene-(substituted or unsubstituted heteroaryl);
• or
• two R13 groups attached to the same N atom are taken together with the N atom to which they are attached to form a substituted or unsubstituted C2-C10heterocycloalkyl.