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US 8,524,742 B2Granted
Use of 5H-thioeno(3,4-c)pyrrole-4,6-dione derivatives as tumor necrosis factor inhibitor
AssigneeTianjin Hemay Bio-Tech Co., Ltd.
InventorHesheng Zhang
Life of this patent
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Abstract
A method of treating or curing a disease caused by or associated with elevated levels of TNF in a patient including administering to the patient 5H-thioeno(3,4-c)pyrrole-4,6-dione derivatives.
Claims11
A method of decreasing tumor necrosis factor-alpha levels in blood of a patient in need thereof, the method comprising administering to the patient a compound represented by formula (I),
- an organic salt thereof, or an inorganic salt thereof, wherein
- R1 represents H, NO2, NHC(O)R6, or NR7R8;
- R2 represents H or CH3;
- R3 represents H, methyl, isopropyl, allyl, benzyl, CH2CO2 (C1-6alkyl), or CH2(CH2)nR9;
- R6, R7, and R8 each independently and at each occurrence represent H, or C1-6 alkyl;
- R9 represents H, C1-6alkyl, OH, C1-6alkyloxy, NH2, C1-6 alkylamino, N(C1-6alkyl)2, or CO2(C1-6alkyl);
- and
- n represents 1, 2, 3, or 4.
5 more elements
A method of inhibiting release of tumor necrosis factor-alpha in monocytes stimulated by lipid polysaccharide in vitro, the method comprising adding to the monocytes a compound represented by formula (I),
- an organic salt thereof, or an inorganic salt thereof, wherein
- R1 represents H, NO2, NHC(O)R6, or NR7R8;
- R2 represents H or CH3;
- R3 represents H, methyl, isopropyl, allyl, benzyl, CH2CO2 (C1-6alkyl), or CH2(CH2)nR9;
- R6, R7, and R8 each independently and at each occurrence represent H, or C1-6 alkyl;
- R9 represents H, C1-6alkyl, OH, C1-6alkyloxy, NH2, C1-6 alkylamino, N(C1-6alkyl)2, or CO2(C1-6alkyl);
- and
- n represents 1, 2, 3, or 4.
5 more elements
Dependencies are inferred from the claim text.