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US 8,524,735 B2Granted
Aerosolized fluoroquinolones and uses thereof
AssigneeMpex Pharmaceuticals, Inc.
InventorsMark W. Surber, Keith A. Bostian, Michael N. Dudley, Olga Lomovskaya, David C. Griffith
Life of this patent
Estimating the term…
Abstract
Disclosed herein are formulations of fluoroquinolones suitable for aerosolization and use of such formulations for aerosol administration of fluoroquinolone antimicrobials for the treatment of pulmonary bacterial infections. In particular, inhaled levofloxacin specifically formulated and delivered for bacterial infections of the lungs is described. Methods include inhalation protocols and manufacturing procedures for production and use of the compositions described.
Claims16
A kit comprising:
- a sterile single use container comprising an aqueous solution of levofloxacin or ofloxacin and a divalent or trivalent cation, wherein the solution is suitable for inhalation into a lung;
- and
- a nebulizer adapted to receive solution from the container and to aerosolize the solution for delivery to the lung through oral inhalation.
A system, comprising:
- a reservoir comprising an aqueous solution of levofloxacin or ofloxacin and a divalent or trivalent cation, wherein the solution is suitable for inhalation into a lung;
- and
- a nebulizer configured to aerosolize the solution for delivery to the lung through oral inhalation.
Dependencies are inferred from the claim text.