Use of opioid antagonists to attenuate endothelial cell proliferation and migration
AssigneeThe University of Chicago
InventorsJonathan Moss, Mark Lingen, Patrick A. Singleton, Joe G. N. Garcia, Chun-Su Yuan
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Abstract
The invention provides methods of attenuating, e.g., inhibiting or reducing, cellular proliferation and migration, particularly endothelial cell proliferation and migration, including that associated with angiogenesis, using opioid antagonists, including, but not limited to, those that are peripherally restricted antagonists.
Claims10
A method of treatment of a disorder characterized by VEGF-induced hyperproliferation of endothelial cells, comprising administering to a subject in need thereof an effective amount of methylnaltrexone and an antiangiogenic agent which is bevacizumab, wherein the disorder is cancer.
Dependencies are inferred from the claim text.