Spirochromanone carboxylic acids

A compound of general formula (I-1):

• wherein A10 represents a linking group formed from a carbo- or heterocyclic ring selected from a group consisting of a benzene ring, a pyridine ring, a piperidine ring, in which said linking group optionally has substituent(s) selected from a group consisting of a halogen atom, a nitro group, a cyano group, a hydroxyl group, a C1-C6 alkyl group, a halo-C1-C6 alkyl group, a hydroxy-C1-C6 alkyl group, a cyclo-C3-C6 alkyl group, a C2-C6 alkenyl group, a C1-C6 alkoxy group, a halo-C1-C6 alkoxy group, a C1-C6 alkylthio group, a C2-C7 alkanoylamino group, a C1-C6 alkylcarbamoyl group, a cyclo-C3-C6 alkylcarbamoyl group, a (C1-C6 alkoxy-C1-C6 alkyl)carbamoyl group, a C2-C7 alkoxycarbonyl group, a C1-C6 alkylsulfonyl group, a C1-C6 alkylsulfonylamino group and a tetrazolyl group;
• Ar10 represents a group formed from an aromatic ring selected from a group consisting of a benzene ring, optionally having substituent(s) selected from R3;
• R20 represents a hydrogen atom, a halogen atom, a C1-C6 alkyl group or a C1-C6 alkoxy group;
• U is a methine group;
• R1 is a 3-pyridyl, 2-pyridyl, 5-pyrazoyl, 4-pyrazoyl, or phenyl group optionally having substituent(s) selected from a group consisting of and an amide group;
• and
• R3 represents a C1-C6 alkyl group, a cyclo-C3-C6 alkyl group, a phenyl group and a C1-C6 alkoxy group;
• or a pharmaceutically acceptable salt thereof.