Amido derivatives and their use as positive allosteric modulators of metabotropic glutamate receptors
AssigneeAddex Pharma SA
InventorChristelle Bolea
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Abstract
The present invention relates to novel compounds of Formula (I), wherein X1, X2, X3, X4, Am and Bn are defined as in Formula (I); invention compounds are modulators of metabotropic glutamate receptors—subtype 4 (“mGluR4”) which are useful for the treatment or prevention of central nervous system disorders as well as other disorders modulated by mGluR4 receptors. The invention is also directed to pharmaceutical compositions and the use of such compounds in the manufacture of medicaments, as well as to the use of such compounds for the prevention and treatment of such diseases in which mGluR4 is involved.
Claims6
A compound selected from the group consisting of:
- N-(3-Chloro-4-(pyrimidin-2-yloxy)phenyl)-2-methylthiazole-4-carboxamide,
- N-(3-Chloro-4-(pyrimidin-2-yloxy)phenyl)thiazole-2-carboxamide,
- N-(3-Chloro-4-(pyridin-2-yloxy)phenyl)picolinamide,
- N-(3-Chloro-4-(2,5-difluorophenoxy)phenyl)picolinamide,
- N-(3-Chloro-4-(2-chlorophenoxy)phenyl)picolinamide,
- N-(3-Chloro-4-(5-(trifluoromethyl)pyridin-2-yloxy)phenyl)picolinamide,
- N-(3-Methoxy-4-(pyrimidin-2-yloxy)phenyl)picolinamide,
- N-(3-Chloro-4-(3-chlorophenoxy)phenyl)picolinamide,
- N-(3-Chloro-4-(3-fluorophenoxy)phenyl)picolinamide,
- N-(3-Chloro-4-(4-fluorophenoxy)phenyl)picolinamide,
- N-(3-Chloro-4-(4-chlorophenoxy)phenyl)picolinamide,
- N-(3-Chloro-4-(4-cyanophenoxy)phenyl)picolinamide;
- and
- N-(3-Chloro-4-(3-cyanopyridin-2-yloxy)phenyl)picolinamide
- or a pharmaceutically acceptable acid or base addition salt thereof, or a stereochemically isomeric form thereof, or a N-oxide form thereof.
Dependencies are inferred from the claim text.