Phenoxyacetic acid derivatives useful for treating respiratory diseases

A compound of formula (I) or a pharmaceutically acceptable salt thereof:

• in which:
• R1 and R2 independently represent a hydrogen atom, halogen, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl or a C1-6alkyl group, the latter four groups being optionally substituted by one or more substituents independently selected from halogen, C3-C7 cycloalkyl, NR9R10, OR8, S(O)nR7 (where n is 0, 1 or 2);
• or
• R1 and R2 together can form a 3-8 membered ring optionally containing one or more atoms selected from O, S, NR11 and itself optionally substituted by one or more C1-C3 alkyl or halogen;
• W is halogen, cyano, nitro, SO2R7, SO2NR9R10, OR8, or C1-6alkyl, the latter being optionally substituted by one or more substituents independently selected from halogen, OR8 and NR7R8, S(O)nR5 where n is 0, 1 or 2;
• R3 is one or more substituents independently selected from hydrogen, halogen, CN, nitro, SO2R7, OR8, SR7, SOR7, SO2NR9R10, CONR9R10, NR9R10, NR11SO2R7, NR11CO2R7, NR11COR7 or C1-6alkyl, the latter being optionally substituted by one or more substituents independently selected from halogen, OR8 and NR9R10, S(O)nR7 where n is 0, 1 or 2;
• X represents a bond, or C1-C6 alkyl, optionally substituted by one or more substituents independently selected from halogen, C1-C6 alkyl the latter being optionally substituted by one or more substituents independently selected from halogen, OR6 and NR7R8, S(O)nR5 where n is 0, 1 or 2;
• Y represents a diamine of the following type:—
• R4 and R5 independently represent hydrogen, SO2R7, C(O)R7, CO2R7 and C1-C6 alkyl, the latter being optionally substituted by one or more substituents independently selected from aryl, heteroaryl, halogen, OR8 and NR9R10, S(O)nR7 where n is 0, 1 or 2;
• R4 and R5 are joined together or one of R4 and R5 is joined onto P or Q to form a saturated heterocyclic 3-10 membered ring with, 1 or 2 endocyclic nitrogen atoms;
• P and Q independently represent, C1-C6 alkyl optionally substituted by one or more substituents independently selected from (═O), halogen, OR8 and NR9R10, S(O)nR7 (where n is 0, 1 or 2), C1-C6 alkyl, C3-C6 cycloalkyl, aryl or heteroaryl (the latter two being optionally substituted by one or more substituents independently selected from halogen, OR8 and NR9R10, CONR9R10, S(O)nR7 where n is 0, 1 or 2);
• Z represents a bond, (CR12)n—C(O), (CR12)n—S(O)n, C(O)(CR12)n, or S(O)2(CR12)n, S(O)2N(CR12)n, where n=0, 1 or 2;
• HET represents aryl or heteroaryl;
• R6 represents one or more substituents independently selected from hydrogen, halogen, CN, nitro, COR7, CO2R8, SO2R7, OR8, SR8, SOR7, SO2NR9R10, CONR9R10, NR9R10, NR8SO2R7, NR8CO2R8, NR8COR7, NR8CONR9R10, NR8SO2NR9R10, aryl, heteroaryl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl or C1-6alkyl, the latter four groups being optionally substituted by one or more substituents independently selected from halogen, C3-C7 cycloalkyl, CN, OR8, NR9R10, S(O)nR7 (where n is 0, 1 or 2), CONR9R10, NR8COR7, SO2NR9R10 and NR8SO2R7;
• R7 represents a C1-C6 alkyl, an aryl or a heteroaryl group all of which may be optionally substituted by halogen atoms, OR8, NR14R15;
• R8 represents hydrogen, C1-C6, alkyl, an aryl or a heteroaryl group all of which may be optionally substituted by halogen atoms, OR8, NR14R15;
• R9 and R10 independently represent hydrogen, C3-C7 cycloalkyl or C1-6alkyl, the latter two groups being optionally substituted by one or more substituents independently selected from halogen, C3-C7 cycloalkyl, OR6 and NR14R15, S(O)nR6 (where n=0, 1 or 2), CONR7R8, NR6COR7,SO2NR7R8 and NR6SO2R5;
• or
• R9 and R10 together with the nitrogen atom to which they are attached can form a 3-8 membered saturated heterocylic ring optionally containing one or more atoms selected from 0, S(O)n (where n=0, 1 or 2), NR13, and itself optionally substituted by halogen or C1-3 alkyl;
• R11 represents a hydrogen atom, C(O)R9, C1-C6 alkyl an aryl or a heteroaryl group (the latter three can be optionally substituted by halogen);
• R12 reperesents one or more from hydrogen, or a C1-6alkyl group, the latter being optionally substituted by one or more substituents independently selected from halogen, C3-C7 cycloalkyl, NR14R15, OR8, S(O)nR7 (where n is 0, 1 or 2);
• R13 represent hydrogen, C1-4 alkyl, —COC1-C4 alkyl, COYC1-C4alkyl where Y is O or NR7;
• and
• R14 and R15 independently represent hydrogen, C1-4 alkyl;
• or
• R14 and R15 together with the nitrogen atom to which they are attached can form a 3-8 membered saturated heterocylic ring optionally containing one or more atoms selected from 0, S(O)n (where n=0, 1 or 2), NR13, and itself optionally substituted by halogen or C1-3 alkyl.