7-phenylalkyl substituted 2-quinolinones and 2-quinoxalinones as poly(ADP-ribose) polymerase inhibitors

A combination of a compound with a chemotherapeutic agent wherein said compound is a compound of

• an N-oxide form, a pharmaceutically acceptable salt or a stereo-chemically isomeric form thereof, wherein
• n is 0, 1 or 2;
• X is N or CR7, wherein R7 is hydrogen;
• R1 is C1-6alkyl;
• R2 is hydrogen, hydroxy, C1-6alkyl, or C3-6alkynyl;
• R3 is a radical selected from
• —(CH2)s—NR8R9 (a-1),
• —O—H (a-2), or
• —O—R10 (a-3),
• wherein
• s is 0, 1, 2 or 3;
• R8 and R10 are each independently selected from —CHO, C1-6alkyl, hydroxyC1-6alkyl, C1-6alkylcarbonyl, amino, C1-6alkylamino, di(C1-6alkyl)aminoC 1-6alkyl, C1-6alkyloxycarbonyl, C1-6alkylcarbonylamino C1-6alkyl, piperidinylC1-6alkylaminocarbonyl, piperidinyl, piperidinylC1-6alkyl, piperidinylC1-6alkylaminocarbonyl, C1-6alkyloxy, thienylC1-6alkyl, pyrrolylC1-6alkyl, arylC1-6alkylpiperidinyl, arylcarbonylC1-6alkyl, arylcarbonylpiperidinylC1-6alkyl, haloindozolylpiperidinylC1-6alkyl, or arylC1-6alkyl(C1-6alkyl)aminoC1-6alkyl;
• and
• R9 is hydrogen or C1-6alkyl;
• or R3 is a group of formula
• —(CH2)t—Z— (b-1),
• wherein
• t is 0,1,2 or 3;
• Z is a heterocyclic ring system selected from
• wherein each R12 independently is hydrogen, halo, C1-6alkyl, aminocarbonyl, amino, hydroxy, aryl,
• C1-6alkylaminoC1-6alkyloxy, C1-6alkyloxyC1-6alkyl, C1-6alkyloxyC1-6alkylamino, arylC1-6alkyl, di(phenyl)C1-6alkenyl, piperidinyl, piperidinylC1-6alkyl, C3-10cycloalkyl, C3-10cycloalkylC1-6alkyl, aryloxy(hydroxy)C1-6alkyl, haloindazolyl, arylC1-6alkyl, arylC2-6alkenyl, arylC1-6alkylamino, morpholino, C1-6alkylimidazolyl, or pyridinylC1-6alkylamino;
• each R13 independently is hydrogen, piperidinyl or aryl;
• R4, R5 and R6 are each independently selected from hydrogen, halo, trihalomethyl, trihalomethoxy, C1-6alkyl, C1-6alkyloxy, amino, aminoC1-6alkyl, di(C1-6alkyl)amino, di(C1-6alkyl)aminoC1-6alkyloxy or C1-6alkyloxycarbonyl, or C1-6alkyl substituted with 1, 2 or 3 substituents independently selected from hydroxy, C1-6alkyloxy, or aminoC1-6alkyloxy;
• aryl is phenyl or phenyl substituted with halo, C1-6alkyl or C1-6alkyloxy.