Pyrrolidine derivatives

A compound of formula (I)

• wherein
• R1 is selected from the group consisting of hydrogen, alkyl, morpholinyl, haloalkylamino, alkyloxadiazolyl, hydroxyl, halopyrrolidinyl, azetidinyl, alkylamino, amino, cyanoalkylamino, halophenylalkylamino and cyanocycloalkylamino;
• R2, R3, R4, R5 and R6 are each independently selected from the group consisting of hydrogen, alkyl, haloalkyl, hydroxyalkyl, alkoxy, haloalkyloxy, halogen, hydroxyl, cyanopyrazinyloxy, pyrazolyl, alkylpyrazolyl, imidazolyl, benzoimidazolyl, 6-oxo-6H-pyridazinyl, alkyl-6-oxo-6H-pyridazinyl, piperazinyl, N-alkylpiperazinyl, piperidinyl, difluoropyrrolidinyl, phenylimidazolyl, oxo-pyrrolidinyl, oxo-oxazolidinyl, morpholinyl, oxo-morpholinyl, oxo-pyridinyl, 2-oxo-2H-pyrazinyl, difluoropiperidinyl, haloalkylpiperidinyl, piperidinylalkoxy, oxetanyloxy, alkylpyrazolyl, halopyridinyl, alkylpyridinyl, cycloalkyl, cycloalkylalkyl, halophenyl, alkylcarbonylaminocycloalkylalkyl, haloalkylpiperazinyl, alkylamino, alkoxyalkylpiperazinyl, cycloalkylpiperazinyl, hexahydropyrrolo[1,2-a]pyrazinyl, 5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl, alkylimidazolyl, azetidinyl, cycloalkylpiperazinyl, alkylimidazolyl, alkoxyalkoxy, imidazo[4,5-c]pyridinyl, alkylpiperazinyl, hexahydro-pyrrolo[1,2-a]pyrazinyl, haloazetidinyl, pyrimindinyl and alkenyloxy;
• A1 is —CH2—, carbonyl, —C(O)O— or absent;
• A2 is nitrogen or CR7;
• A3 is nitrogen or CR8;
• A4 is nitrogen or CR9;
• R7 is selected from the group consisting of hydrogen, alkyl, haloalkyl, halogen, hydroxyl, haloalkylaminocarbonyl;
• halophenylalkylaminocarbonyl, phenylcycloalkylaminocarbonyl, haloalkylphenylalkylaminocarbonyl, halophenylcycloalkylaminocarbonyl and halophenylcycloalkylalkylaminocarbonyl;
• R8 is selected from the group consisting of hydrogen, alkyl, haloalkyl, halogen and hydroxyl;
• or R7 and R8 together with the carbon atom to which they are attached form cycloalkyl or substituted pyrrolidine, wherein substituted pyrrolidine is pyrrolidine N-substituted with haloalkyl or formyl;
• R9 is selected from the group consisting of hydrogen, alkyl, haloalkyl, halogen and nitro;
• or R8 and R9 together with the carbon atom to which they are attached form cycloalkyl;
• or a pharmaceutically acceptable salt thereof.