1,4-diazabicyclo[3.2.2]nonanecarboxamide derivatives, preparation and therapeutic use thereof

A compound of formula (I):

• in which
• X represents a nitrogen atom or a group of formula C—R2,
• P represents a group of formula C—R3,
• Q represents a group of formula C—R4,
• R represents a group of formula C—R5,
• W represents a group of formula C—R6,
• or one of the symbols P, Q, R and W represents a nitrogen atom,
• R1 represents a hydrogen atom or a (C1-C6)alkyl group,
• R2 represents a hydrogen atom or a (C1-C6)alkyl group,
• R3 and R5 each represent, independently of each other, a hydrogen or halogen atom, or a (C1-C6)alkyl, (C1-C6)alkoxy, nitro, amino, trifluoromethyl or cyano group, or a group of formula —NR7R8, —NR7C(═O)R8, —NR7C(═O)NR8R9, —NR7C(═O)OR8, —NR7S(═O)2NR8R9, —OR7, —OC(═O)R7, —OC(═O)OR7, —OC(═O)ONR7R8, —OC(═O)SR7, —C(═O)OR7, —C(═O)R7, —C(═O)NR7R8, —SR7, —S(═O)R7, —S(═O)2R7, or —S(═O)2NR7R8,
• one of R4 and R6 is hydrogen and the other is —OS(═O)2R7, (C6-C11)aryl or (C3-C12)heteroaryl, optionally substituted with one or more groups chosen from halogen atoms and (C1-C6)alkyl, (C1-C6)alkoxy, nitro, amino, trifluoromethyl, and cyano groups, or groups of formula —NR7R8 or —OR7, wherein when R4 or R6 represents a (C3-C12)heteroaryl, the heteroaryl is selected from the group consisting of thienyl, furyl, pyrrolyl, and pyridyl;
• R7, R8 and R9 each represent, independently of each other, a hydrogen atom or a linear or branched (C1-C6)alkyl group, a linear or branched (C2-C6)alkenyl group, a linear or branched (C2-C6)alkynyl group, a (C3-C8)-cycloalkyl or (C4-C8)cycloalkenyl group, or a heterocycloalkyl group containing 3 to 8 atoms in the ring, or a (C5-C11)bicycloalkyl or (C7-C11)bicycloalkenyl group, a heterobicycloalkyl group containing 5 to 11 atoms in the ring, a bicycloheteroalkenyl group containing 5 to 11 atoms in the ring, or a (C6-C11)aryl or heteroaryl group containing 5 to 12 atoms in the ring,
• R7, R8 and R9 may be optionally substituted, independently of each other, with a halogen atom or a (C1-C6)alkyl, (C1-C6)alkoxy, nitro, amino, trifluoromethyl or cyano group, or a group of formula —NR10R11, —NR10C(═O)R11, —NR10C(═O)NR11R12, —NR10C(═O)OR11, —NR10S(═O)2NR11R12, —OR10, —OC(═O)R10, —OC(═O)OR10, —OC(═O)ONR10R11, —OC(═O)SR10, —C(═O)OR10, —C(═O)R10, —C(═O)NR10R11, —SR10, —S(═O)R10, —S(═O)2R10, —S(═O)2NR2R11,
• R10, R11 and R12 each represent, independently of each other, a hydrogen atom or a linear or branched (C1-C6)alkyl group, a linear or branched (C2-C6)alkenyl group, a linear or branched (C2-C6)alkynyl group, a (C3-C8)-cycloalkyl or (C4-C8)cycloalkenyl group, a heterocycloalkyl group containing 3 to 8 atoms in the ring, a (C5-C11)bicycloalkyl or (C7-C11)bicycloalkenyl group, a heterobicycloalkyl group containing 5 to 11 atoms in the ring, a bicycloheteroalkenyl group containing 5 to 11 atoms in the ring, or a (C6-C11)aryl or heteroaryl group containing 5 to 12 atoms in the ring,
• R10, R11 and R12 may be optionally substituted, independently of each other, with a halogen atom or a (C1-C6)alkyl, (C1-C6)alkoxy, nitro, amino, trifluoromethyl or cyano group, or —NR13R14, —NR13C(═O)R14, —NR13C(═O)NR14R15, —NR13C(═O)OR14, —NR13S(═O)2NR14R15, —OR13, —OC(═O)R13, —OC(═O)OR13, —OC(═O)ONR13R14, —OC(═O)SR13, —C(═O)OR13, —C(═O)R13, —C(═O)NR13R14, —SR13, —S(═O)R13, —S(═O)2R13, —S(═O)2NR13R14,
• R13, R14 and R15 each represent, independently of each other, a hydrogen atom or a linear or branched (C1-C6)alkyl group, a linear or branched (C2-C6)alkenyl group, a linear or branched (C2-C6)alkynyl group, a (C3-C8)-cycloalkyl or (C4-C8)cycloalkenyl group, a heterocycloalkyl group containing 3 to 8 atoms in the ring, a (C5-C11)bicycloalkyl or (C7-C11)bicycloalkenyl group, a heterobicycloalkyl group containing 5 to 11 atoms in the ring, a bicycloheteroalkenyl group containing 5 to 11 atoms in the ring or a (C6-C11)aryl or heteroaryl group containing 5 to 12 atoms in the ring, and
• R3 and R4, or R4 and R5, or R5 and R6, may together form, with the two carbon atoms that bear them, another aromatic or heteroaromatic ring containing 6 atoms in the ring, optionally substituted with 1 to 4 substituents chosen from those defined for R7, R8 and R9,
• or an addition salt thereof.