2-oxo-2-(2-phenyl-5,6,7,8-tetrahydro-indolizin-3-yl)-acetamide derivatives and related compounds as antifungal agents

A tetrahydroindolizine derivative of formula (I), or a pharmaceutically or agriculturally acceptable salt thereof:

• wherein:
• R1 represents hydrogen, unsubstituted or substituted C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, —COR′ or —SO2(C1-C4 alkyl), or a group -A2, -L2-A2, -L3-A2 or -A2-L3-A3;
• A1, A2 and A3 are the same or different and represent C3-C6 cycloalkyl or an unsubstituted or substituted C6-C10 aryl or 5- to 12-membered heterocyclyl group;
• L1 represents a bond, a C1-C6 alkylene group in which none, one, two or three —CH2— groups are independently replaced by —O—, —S— or —NR′—, or a 5- to 12-membered heterocyclyl group;
• L2 represents —NR′—, —O—, —CO—, —OCO—, —OCONR′R″—, —CONR′R″— or —SO2—;
• L3 represents a bond or a C1-C4 alkylene group in which none, one or two —CH2— groups are independently replaced by —O—, —S— or —NR′—;
• n represents 0 or 1;
• R8 represents hydrogen or C1-C4 alkyl;
• R2 represents an unsubstituted or substituted group selected from C6-C10 aryl, a 5- to 12-membered heterocyclyl group, C1-C8 alkyl and C3-C6 cycloalkyl, halogen or a group of formula —B1—B2;
• B1 represents an unsubstituted or substituted C6-C10 aryl group;
• B2 represents an unsubstituted or substituted C6-C10 aryl or 5- to 12-membered heterocyclyl group;
• R3, R4, R5 and R6 independently represent C6-C10 aryl, a 5- to 12-membered heterocyclyl group, —(C1-C4 alkylene)-(C6-C10 aryl), —(C1-C4 alkylene)-(5- to 12-membered heterocyclyl), hydrogen, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, halogen, C3-C6 cycloalkyl, —OR′, —SR′, —SOR′, —SO2R′, —SO2NR′R″, —SO3H, —NR′R″, —NR′COR′, —CO2R′, —CONR′R″, —COR′, —OCOR′, —CF3, —NSO2R′ or —OCONR′R″;
• R7 represents hydrogen, halogen, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, —OR′, —CO2R′, —CONR′R″, —COR′, —CN, —NO2, —NR′R″, CF3, —Y—Z, C6-C10 aryl or a group of formula -Alk6-L5-A12, where Alk6 is a C1-C4 alkylene group, L5 is a group of formula —O—C(═O)—, —C(═O)— or —NR13-C(═O)— and R13 is hydrogen or C1-C4 alkyl, and A12 is an unsubstituted or substituted C6-C10 aryl or 5- to 12-membered heterocyclyl group;
• Y represents C1-C8 alkylene, C2-C8 alkenylene or C2-C8 alkynylene;
• Z represents halogen, C3-C6 cycloalkyl, —OR′, —SR′, —SOR′, —SO2R′, —SO2NR′R″, —SO3H, —NR′R″, —NR′COR′, —NO2, —CO2R′, —CONR′R″, —COR′, —OCOR′, —CN, —CF3, —NSO2R′, —OCONR′R″ or —CR′═NOR″;
• and
• R′ and R″ independently represent hydrogen, C1-C8 alkyl, C2-C8 alkenyl or C2-C8 alkynyl.