C20-C21 substituted glucocorticoid receptor agonists

A compound, or a pharmaceutically acceptable salt, ester, or isomer thereof, of Formula (IV):

• wherein L, R1, R2, R3, R4, R5, and R6 are selected independently of each other and wherein:
• L is —CH2—S—;
• R1 is a benzofused heteroaryl-,
• wherein said R1 group is unsubstituted or optionally substituted with from 1 to 5 substituents, which may be the same or different, each independently selected from halogen, hydroxy, —CN, oxo, oxide, alkyl, haloalkyl, haloalkoxy-, hydroxyalkyl-, heteroalkyl, cyanoalkyl-, alkoxy, optionally substituted aryl, optionally substituted —O-aryl, optionally substituted —O-alkyl-aryl, optionally substituted heteroaryl, optionally substituted arylalkyl-, optionally substituted arylalkoxy, —N(R7)2, -alkylN(R7)2, —NC(O)R7, —CO2R7, —SO2R7, and —SO2N(R7)2, wherein said optional substituents are present from 1 to 4 times and may be the same or different, each independently selected from alkyl, halogen, haloalkyl, hydroxyl, —CN, and —N(R11)2;
• and wherein the benzo portion of each said benzofused R1 group is optionally further fused to another ring selected from heteroaryl, cycloalkyl, cycloalkenyl, heterocycloalkyl, and heterocycloalkenyl,
• R2 is —OR8;
• R3 is selected from hydrogen, hydroxy, and straight or branched alkyl,
• R4 is selected from H and halogen;
• R5 is selected from H, halogen, and alkyl;
• z (the dotted line) represents a single or double bond, with the proviso that when z is a single bond, R6 is H;
• R6 is selected from H and halogen;
• each R7 is independently selected from hydrogen, alkyl, haloalkyl, aryl, and heteroaryl,
• or, when two groups R7 are attached to the same nitrogen atom, two groups R7 are taken together with the nitrogen atom to which they are attached to form a 3- to 7-membered heterocycloalkyl group;
• R8 selected from haloalkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, —C(O)NHR9, and —C(O)R11;
• R9 is selected from alkyl, haloalkyl, aryl, heteroaryl, cycloalkyl, and heterocycloalkyl, each unsubstituted or optionally substituted with from 1 to 4 substituents independently selected from the group consisting of alkyl, halogen, haloalkyl, hydroxy, —N(R7)2, and —CN;
• R10 is selected from hydrogen and alkyl;
• and
• R11 is selected from haloalkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, and heterocycloalkenyl, each unsubstituted or optionally substituted with from 1 to 4 substituents independently selected from the group consisting of alkyl, halogen, haloalkyl, hydroxy, —N(R7)2, and —CN.