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US 8,524,679 B2Granted
In vivo delivery of double stranded RNA to a target cell
AssigneeVeritas Bio, LLC
InventorCatherine Pachuk
Life of this patent
Estimating the term…
Abstract
The invention encompasses methods of delivering nucleic acids, including dsRNA, to mammalian target cells in vivo via intercellular transfer, wherein the dsRNA is delivered to or expressed in a first cell different from the target cell, wherein the first cell facilitates delivery of the dsRNA to the target cell.
Claims17
A method of delivering at least one RNA to liver or liver tissue in an animal comprising:
- transfecting at least one muscle or skin cell of said animal with a double-stranded RNA (dsRNA) or with a nucleic acid encoding said RNA, wherein said transfection results in said RNA being delivered to at least one cell in the liver or liver tissue, wherein one strand of said dsRNA is substantially complementary to a region of RNA produced by a pathogen infecting the liver or liver tissue.
Dependencies are inferred from the claim text.