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US 8,524,677 B2Granted
DNA vaccine as immunoprophylaxis against Kala-azar
AssigneeCouncil of Scientific and Industrial Research
InventorsRajatava Basu, Syamal Roy
Life of this patent
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Abstract
A highly conserved membrane protein present in all species of Leishmania can be used as a vaccine antigen for genetic immunization against visceral leishmananiasis.
Claims10
A method for immunizing a mammal against visceral Leishmania, comprising administering to the mammal a DNA vaccine comprising a mammalian expression vector comprising cDNA encoding a Kinetoplastid Membrane Protein-11 (KMP-11) antigen before virulent Leishmania parasite exposure or infection, wherein
- (1) the antigen is a cell surface membrane protein from a virulent form of Leishmania;
- (2) the antigen confers protection from the parasite;
- and
- (3) the vaccine confers sterile protection in tissues that would be infected by a virulent form of Leishmania upon exposure.
1 more element
A method for immunizing a mammal harboring a lethal dose of virulent Leishmania infection against visceral Leishmania, comprising:
- administering to the infected mammal a DNA vaccine comprising a mammalian expression vector comprising a nucleotide sequence encoding a membrane protein of Leishmania parasites consisting of an antigen known as Kinetoplastid Membrane Protein-11 (KMP-11)
- wherein (1) the antigen comprises a cell surface protein of Leishmania;
- (2) the antigen prevents mortality of the mammal from lethal virulent Leishmania infection;
- and (3) the vaccine confers sterile protection in tissues that would be infected by Leishmania upon exposure.
1 more element
Dependencies are inferred from the claim text.