Cyclosporin derivatives for treating inflammatory diseases and conditions
AssigneeAllergan, Inc.
InventorsMichael E. Garst, Michael E. Stern
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Abstract
The present invention provides a method for the treatment of inflammatory diseases and/or conditions, e.g. allergic conjunctivitis, uveitis or phacoanaphylactic endophthalmitis in an eye of a mammal, said method comprising administering to said mammal in need of treatment a therapeutically effective amount of a novel cyclosporin A derivative selected from the group consisting of compounds represented by the formula: wherein R1 is S-Alk-R wherein Alk is an alkylene linkage, preferably a methylene or poly methylene linkage, or a polyalkenylene linkage, e.g. a C3 to C6 alkenylenyl linkage and R is a hydrogen or a unsubstituted or substituted hydrocarbyl group.
Claims9
A method for the treatment of an inflammatory condition of a mammal, comprising the step of administering to a patient in need thereof, a therapeutically effective amount of a cyclosporin A derivative represented by the following formula:
- wherein R1 is S-Alk-R wherein Alk is an alkylene linkage and, R is —N═C(NR3R4)(NR5R6), wherein R3-R6 is H, Alk, Ar or (CH2)nAr wherein Ar is an aryl group and n is an integer of from 1 to 13 or R3 and R4 or R4 and R5, together may be —CH2—CH2— or —CH2—CH2—CH2—, and R2 is —CH2CH(CH3)2, —CH2C(OH)(CH3)2, —CH(CH3)2 or —CH(CH3)CH2CH3.
Dependencies are inferred from the claim text.