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AssigneeIBCC Holding AS
InventorsTaavi Pall, Wally Anderson, Lagle Kasak, Anne Pink, Priit Kogerman, Aire Allikas, Andres Valkna
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The invention relates to a method of treatment for states related to inhibition of angiogenesis and endothelial cell proliferation comprising administering an effective amount of vimentin or its derivatives or its fragments, to a subject in need thereof. Further, the invention relates to a pharmaceutical composition and a medicament comprising vimentin, as well as the use of vimentin in the manufacture of a medicament. Hereby, angiogenesis and endothelial cell proliferation can be controlled, and therapeutic treatment for related states is provided.
A method to manufacture a medicament for inhibition of angiogenesis or endothelial cell proliferation, said method comprising the use of vimentin according to SEQ ID NO:1, or a fragment thereof comprising SEQ ID NO:12 in the medicament.
A medicament for inhibition of either angiogenesis or endothelial cell proliferation, said medicament comprising a fragment of vimentin, wherein said fragment comprises SEQ ID NO:12.
A pharmaceutical composition for treating states requiring inhibition of either angiogenesis or endothelial cell proliferation in a human, said composition comprising the vimentin of SEQ ID NO:1 or a fragment thereof comprising SEQ ID NO:12, in a mixture or otherwise together with at least one pharmaceutically acceptable carrier or excipient.
A method of inhibiting angiogenesis and endothelial cell proliferation, said method comprising using the vimentin of SEQ ID NO:1, a fragment thereof comprising SEQ ID NO:12, or a vimentin which is at least 95% identical to SEQ ID NO:1.
Dependencies are inferred from the claim text.