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US 8,524,662 B2Granted
Compositions and methods for treating joints
AssigneeDePuy Mitek, LLC
InventorsBen Byers, Dongling Su, Julia Hwang
Life of this patent
Estimating the term…
Abstract
Methods and compositions are disclosed for an intra-articular injection for the treatment of osteoarthritis. The methods and compositions comprising combinations of hyaluronic acid and a bone morphogenetic protein, like rhGDF-5, can be useful for any synovial joint, including the knee, shoulder, hip, ankle, hands, spinal facet, or temporomandibular joint, both for the relief of pain and for slowing disease progression.
Claims17
A composition for treating a joint condition, comprising:
- an injectable formulation comprising a precipitate of a bone morphogenetic protein (BMP) dispersed within a solution of hyaluronic acid (HA), the injectable formulation having a pH of at least about 3 and a concentration of BMP in the range of about 5 μg/mL to about 90 μg/mL, and the BMP being in a precipitated form and capable of becoming solubilized and biologically active after injection into an organism.
A kit, comprising:
- a first component comprising a solution of hyaluronic acid (HA) having a pH in the range of about 3 to 8;
- a second component comprising an amount of a bone morphogenetic protein (BMP) that is in precipitate form and capable of becoming solubilized and biologically active following delivery to an organism;
- and
- a syringe for injecting a mixture of the first component and the second component, wherein the mixture has a concentration of BMP in the range of about 5 μg/mL to about 90 μg/mL.
1 more element
Dependencies are inferred from the claim text.