US 8,524,659 B2 · RNA virus-derived peptides with modified side chains

Abstract

The present invention provides a RNA virus-derived peptides with modified side chains, wherein the side chains of the RNA virus-derived peptide are modified by altering the side-chain length or charges thereof such that the RNA virus-derived peptide has a high binding affinity for viral RNA and an high cellular uptake capability. The present invention also provides a composition for inhibiting RNA virus wherein the RNA virus-derived peptide can effectively inhibit viral self-replication and treat related diseases by its high affinity for viral RNA. A drug delivery carrier is also provided, wherein the RNA virus-derived peptides can carry desired drugs to the intracellular target due to its cellular uptake capability and thereby enhances the drug-delivery and treating efficiency.

Claims11

Dependent claims

A RNA virus-derived peptide with modified side chains, comprising the formula (I):

wherein the n1, n2, n3, n4, n5 and n6 are a positive integer no greater than 8, respectively;
X is NH or O;
Y, Y′ and Y″ are any amino acid side chain group, respectively;
and
the n1, n2, n3, n4, n5 and n6 are not 3 at the same time when X is NH.

2 more elements

Dependencies are inferred from the claim text.

RNA virus-derived peptides with modified side chains

Life of this patent

RNA virus-derived peptides with modified side chains

Life of this patent

Abstract

Claims11