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US 8,524,656 B2Granted
GM-CSF and truncated CCL2 conjugates and methods and uses thereof
OwnerJacques Galipeau, Moutih Rafeiinventors
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Abstract
A conjugate protein comprising a GM-CSF or a fragment thereof and a truncated CCL2 is described. The conjugate protein has unexpected immune suppressive, anti-obesity and tumoricidal properties and is useful in a variety of therapeutic applications.
Claims6
A conjugate protein comprising:
- a. GM-CSF or a N-terminal fragment thereof lacking the last 11 carboxy terminal amino acids of GM-CSF linked to
- b. truncated CCL2, wherein the truncated CCL2 has the first 5 amino acids removed and acts as an antagonist as compared to full length CCL2, wherein the conjugate protein inhibits CCR2 homodimerization.
Dependencies are inferred from the claim text.