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US 8,524,508 B2Granted
Methods of treating neuromyelitis optica (NMO)
AssigneeMayo Foundation for Medical Education and Research
InventorsVanda A. Lennon, Thomas J Kryzer
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Abstract
The present invention provides for methods and materials for diagnosing and treating neuromyelitis optica (NMO).
Claims11
A method of removing autoantibodies against aquaporin-4 from an individual having neuromyelitis optica (NMO), said method comprising:
- withdrawing a body fluid sample from the individual, wherein the body fluid sample contains one or more autoantibodies that bind to aquaporin-4;
- removing, from the body fluid sample, at least 20% of the autoantibodies that bind to aquaporin-4 that are present in the body fluid sample using an antigenic aquaporin-4 polypeptide to produce an autoantibody-depleted body fluid sample;
- and
- returning the autoantibody-depleted body fluid sample to the subject, wherein said removing step and said returning step are performed using apheresis, wherein the body fluid sample is selected from the group consisting of plasma and cerebrospinal fluid.
1 more element
A method of removing T cells from an individual having neuromyelitis optica (NMO), said method comprising:
- withdrawing a body fluid from the individual, wherein the body fluid contains one or more T cells responsible for inducing the production of autoantibodies that bind to aquaporin-4;
- removing T cells from the body fluid using an antibody directed toward an aquaporin-4 marker on said T cells;
- and
- returning the body fluid to the subject, wherein said removing step and said returning step are performed using apheresis, wherein the body fluid is selected from the group consisting of plasma and cerebrospinal fluid.
1 more element
Dependencies are inferred from the claim text.