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US 8,524,463 B2Granted
Diagnosis and risk classification of acute coronary syndrome by means of CT-proET-1 in combination with NT-proBNP
AssigneeB.R.A.H.M.S GmbH
InventorsAndreas Bergmann, Nils Morgenthaler, Jana Papassotiriou, Joachim Struck, Leong L. Ng
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Abstract
The invention relates to a method for diagnosis and/or risk classification for acute coronary syndrome (ACS), in particular for acute myocardial infarct (AMI) and angina pectoris (AP) and/or a post-myocardial infarct, wherein a determination of the C-terminal pro-endothelin (CT-proET-1) or fragments and partial peptides therefrom, is carried out in combination with NT-proBNP.
Claims20
A method for the in-vitro diagnosis or prognosis of acute coronary syndrome, or post-myocardial infarction, comprising
- determining the level of CT-pro-ET-1 in at least one blood sample from a patient, wherein said CT-pro-ET-1 refers to SEQ ID NO:
- 2, or SEQ ID NO:
- 3, or both, and
- determining the level of NT-proBNP (SEQ ID NO:
- 4) in said at least one blood sample from said patient,
- wherein an increased level of CT-pro-ET-1 and an increased level of NT-proBNP in said at least one sample indicates the presence in said patient of acute coronary syndrome, or an increased risk of or an unfavorable prognosis of acute coronary syndrome or post-myocardial infarction for said patient.
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