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US 8,524,462 B2Granted
Methods and compositions for diagnosis and prognosis of renal artery stenosis
AssigneeAlere San Diego, Inc.
InventorsGunars Valkirs, Paul H. McPherson
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Abstract
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects in the context of renal artery stenosis (RAS). In particular, the invention relates to using assays that detect NGAL, their use to diagnose RAS in subjects suffering from hypertension, and their use in prognosis, particularly of mortality and worsening renal function.
Claims11
A method of assigning a risk of an adverse outcome to a patient suffering from renal artery stenosis, comprising:
- performing an immunoassay that detects Neutophil Gelatinase-Associated Lipocalinon (NGAL) on a body fluid sample obtained from said patient, wherein said immunoassay comprises (a) contacting said body fluid sample with a solid phase comprising an antibody that detects NGAL, and (b) detecting binding to said antibody, thereby providing an NGAL assay result;
- comparing said NGAL assay result to a baseline NGAL result;
- and
- relating the NGAL assay result to the patient's risk of an adverse outcome by assigning an increased risk of an adverse outcome to said patient when said NGAL assay result is greater than said baseline NGAL result, or by assigning a decreased risk of an adverse outcome to said patient when said NGAL assay result is less than said baseline NGAL result.
1 more element
Dependencies are inferred from the claim text.