Detect and identify virus by the microwave absorption spectroscopy
AssigneeNational Taiwan University
InventorsChi-Kuang Sun, Tzu-Ming Liu, Hung-Pin Chen
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Abstract
The present invention discloses microwave resonant absorption (MRA) of viruses through dipolar coupling to viral confined acoustic modes. The unique geometrical and mechanical properties of viruses can be reflected by the MRA frequencies, MRA linewidth, and the absorption selection rules of high-order acoustic modes. Combined these spectral characteristics with the mature microwave technology, this invention provides a novel physical mechanism to develop non-affinity-based rapid detection and identification of viruses. It can be applied in preliminary characterization on unknown or mutant viruses.
Claims6
A method for establishing a virus spectrum comprising (1) preparing a sample containing a purified known virus;
- (2) dropping the sample on a coplanar waveguide (CPW) circuit;
- (3) applying a microwave with frequencies ranging from 40 MHZ to 80 GHZ to the sample on the coplanar waveguide (CPW) circuit;
- (4) applying a network analyzer with frequencies ran in from 40 MHZ to 65 GHZ to simultaneously record reflection S11 and transmission S21 parameters of the CPW circuit;
- (5) evaluating an insertion power loss by 1−|S11|2−|S21|2;
- and (6) obtaining an MRA spectrum under a dipolar acoustic mode of the virus by comparing insertion power loss spectra of the sample with and without the virus.
Dependencies are inferred from the claim text.