Charge-dynamic polymers and delivery of anionic compounds
AssigneeWisconsin Alumni Research Foundation
InventorsDavid M. Lynn, Adam D. Miller
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Abstract
The present invention provides dynamic charge state cationic polymers that are useful for delivery of anionic molecules. The dynamic charge state cationic polymers are designed to have cationic charge densities that decrease by removal of removable functional groups from the polymers. The present invention also provides interpolyelectrolyte complexes containing the polymers complexed to a polyanion. Methods for using the interpolyelectrolyte complexes to deliver anionic compounds are also provided.
Claims33
A multilayered interpolyelectrolyte complex comprising a first layer comprising a first interpolyelectrolyte complex and a second layer comprising a second interpolyelectrolyte complex, wherein each of the first and second interpolyelectrolyte complexes, independently from one another, comprise:
- a. a dynamic charge state cationic polymer having a polymeric backbone formed from monomeric units, and one or more removable functional groups attached to the polymeric backbone through one or more labile linkages, wherein the one or more removable functional groups are selected from the group consisting of an ester, anhydride, orthoester, phosphorester, acetal, amide, amino, alkylamino, cyano, carbamoyl, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclic, aryl, and heteroaryl group;
- and
- b. one or more anions complexed to said cationic polymer;
- wherein the overall positive charge of the cationic polymer decreases when one or more of the removable functional groups is removed from the polymeric backbone, thereby causing said one or more anions to disassociate from the cationic polymer,
- wherein the cationic polymer and one or more anions in the first interpolyelectrolyte complex can be the same or different from the cationic polymer and one or more anions in the second interpolyelectrolyte complex.
A multilayered interpolyelectrolyte complex comprising two or more layers, wherein a first layer comprises a first interpolyelectrolyte complex and a second layer comprising a second interpolyelectrolyte complex, wherein each of the first and second interpolyelectrolyte complexes, independently from one another, comprise:
- a. a dynamic charge state cationic polymer having a polymeric backbone formed from monomeric units, and one or more removable functional groups attached to the polymeric backbone through one or more labile linkages, wherein the one or more removable functional groups are removed via hydrolysis;
- and
- b. one or more anions complexed to said cationic polymer;
- wherein the overall positive charge of the cationic polymer decreases when one or more of the removable functional groups is removed from the polymeric backbone, thereby causing said one or more anions to disassociate from the cationic polymer,
- wherein the cationic polymer and one or more anions in the first interpolyelectrolyte complex can be the same or different from the cationic polymer and one or more anions in the second interpolyelectrolyte complex.
A multilayered interpolyelectrolyte complex comprising two or more layers, wherein a first layer comprises a first interpolyelectrolyte complex and a second layer comprising a second interpolyelectrolyte complex, wherein each of the first and second interpolyelectrolyte complexes, independently from one another, comprise:
- a. a dynamic charge state cationic polymer having a polymeric backbone formed from monomeric units, and one or more removable functional groups attached to the polymeric backbone through one or more labile linkages,
- wherein the polymeric backbone is prepared by conjugating an acrylate to a polyamine selected from the group consisting of:
- polyethyleneimine, poly(propylene imine), poly(allyl amine), poly(vinyl amine), or poly(amidoamine),
- wherein the one or more removable functional groups are removed via hydrolysis;
- and
- b. one or more anions complexed to said cationic polymer;
- wherein the overall positive charge of the cationic polymer decreases when one or more of the removable functional groups is removed from the polymeric backbone, thereby causing said one or more anions to disassociate from the cationic polymer,
- wherein the cationic polymer and one or more anions in the first interpolyelectrolyte complex can be the same or different from the cationic polymer and one or more anions in the second interpolyelectrolyte complex.
Dependencies are inferred from the claim text.