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AssigneeKorea Institute of Science and Technology
InventorsChu Won Nho, Na Ra Jeon, Kyung Su Kang, Saet Byoul Lee, Ji Hye Yoo, Suk Woo Kang, Byung Hun Um, Cheol-Ho Pan
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The present invention relates to a method for the prevention and treatment of postmenopausal syndrome containing the step of administering a pharmaceutically effective dose of the Aceriphyllum rossii or its fractions to a subject. The present inventors confirmed that the Aceriphyllum rossii extract or its fractions of the invention prepared by using water, alcohol or a mixed solvent thereof could promote the expression of the promoter containing estrogen responsive element (ERE) and accelerated the growth of MCF-7, the human breast tissue originated cell line, suggesting that they had estrogen activity. The inventors further confirmed that the extract or its fractions of the invention had the effect of promoting osteocyte differentiation, so that they could be effectively used for the prevention and treatment of postmenopausal syndrome such as hot flush, osteoporosis and phlebothrombosis caused by estrogen deficiency.
A method for promoting differentiation of embryonic fibroblasts and generating osteocytes in vitro comprising treating embryonic fibroblasts with an effective amount of an ethanol extract of Aceriphyllum rossii or an ethyl acetate fraction of said ethanol extract.
Dependencies are inferred from the claim text.