Spray drying methods and related compositions
AssigneeNovartis AG
InventorsHerman E. Snyder, Michael J. Vosberg, Christopher M. Varga
Life of this patent
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Abstract
A method and apparatus are provided for atomizing a liquid under dispersal conditions suitable for spray drying at a commercial plant scale. In one embodiment, a liquid atomizer has a structural body adapted for connection with a spray dryer and a plurality of atomizing nozzles. Each of the atomizing nozzles includes a liquid nozzle adapted to disperse a supply of liquid and a gas nozzle adapted to disperse a supply of gas. In another embodiment, a process for producing a powder blend of at least two target substances in a single processing step is provided.
Claims26
A method for making a powder pharmaceutical for pulmonary administration, the method comprising:
- providing a feedstock containing an active agent in a liquid vehicle, wherein the active agent comprises one or more of an antibiotic, an anti-inflammatory agent, and a bronchodilator;
- providing a multi-nozzle atomizer comprising a housing supporting a central gas nozzle and a plurality of atomization nozzles around the central gas nozzle, wherein each atomization nozzle comprises a liquid nozzle and a gas nozzle that is configured as a cap surrounding the liquid nozzle, and wherein the central gas nozzle is not associated with a liquid nozzle;
- atomizing the feedstock from the multi-nozzle atomizer to produce a droplet spray, wherein the feedstock is fed through the housing to the liquid nozzles in each of the atomization nozzles;
- and
- flowing the droplet spray in a heated gas stream to evaporate the liquid vehicle of the feedstock and produce a powder of dry particulates comprising the active agent, wherein the dry particulates have an average particle size of less than 5 microns.
A method for making a powder pharmaceutical for pulmonary administration, the method, comprising:
- providing a feedstock containing an active agent in a liquid vehicle, wherein the active agent comprises an antibiotic, wherein the antibiotic comprises one or more of ciprofloxacin, tobramycin, clarithromycin, gentamicin, and azithromycin;
- providing a multi-nozzle atomizer comprising a plurality of atomization nozzles, wherein each atomization nozzle comprises a liquid nozzle and a gas nozzle;
- atomizing the feedstock from the multi-nozzle atomizer to produce a droplet spray, wherein the feedstock is from a single source and is fed to the liquid nozzles in each of the atomization nozzles;
- and
- flowing the droplet spray in a heated gas stream to evaporate the liquid vehicle of the feedstock and produce a powder of dry particulates comprising the active agent, wherein the dry particulates have an average particle size of less than 5 microns.
A method for making a powder pharmaceutical for pulmonary administration, the method comprising:
- providing a feedstock containing an active agent in a liquid vehicle;
- providing a multi-nozzle atomizer comprising a housing supporting a central gas nozzle and a plurality of atomization nozzles around the central gas nozzle, wherein each atomization nozzle comprises a liquid nozzle and a gas nozzle that is configured as a cap surrounding the liquid nozzle, and wherein the central gas nozzle is not associated with a liquid nozzle, wherein each of the plurality of atomization nozzles is disposed at an angle away from the atomizer centerline that ranges from 10° to 40°;
- atomizing the feedstock from the multi-nozzle atomizer to produce a droplet spray, wherein the feedstock is fed through the housing to the liquid nozzles in each of the atomization nozzles;
- and
- flowing the droplet spray in a heated gas stream to evaporate the liquid vehicle of the feedstock and produce a powder of dry particulates comprising the active agent, wherein the dry particulates have an average particle size of less than 5 microns.
Dependencies are inferred from the claim text.