Extended release dosage form
AssigneeAlza Corporation
InventorsDavid E. Edgren, Patrick S.-L. Wong, Gurdish K. Bhatti, Shu Li, Robert R. Skluzacek
Life of this patent
Estimating the term…
Abstract
A membrane system comprising an interior wall, a fluid-permeable exterior wall surrounding the interior wall and an internal compartment defined by the membrane system, wherein fluid permeability of the interior wall is responsive to osmolarity of an osmotic core within the internal compartment are disclosed. A controlled release dosage form comprising the membrane system and a process for delivering an osmotically active formulation from an osmotic pump over an extended period of time are also disclosed.
Claims1
A therapeutic solid, sustained-release composition comprising 1 mg to 1000 mg of an opioid analgesic, 1 mg to 1000 mg of a nonopioid analgesic, and a pharmaceutically acceptable polyethylene oxide carrier, wherein the opioid analgesic comprises a member selected from the group consisting of hydrocodone and its pharmaceutically acceptable salts and the nonopioid analgesic comprises acetaminophen, and wherein said composition is coated with a wall comprising ethylcellulose and hydroxypylcellulose.
Dependencies are inferred from the claim text.