Transdermal absorption preparation
AssigneeHisamitsu Pharmaceutical Co., Inc.
InventorsSatoshi Amano, Sachiko Honma, Tetsuro Tateishi, Natsumi Kase
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Abstract
A transdermal absorption preparation having a support and a pressure-sensitive adhesive layer consisting of multiple layers, wherein the pressure-sensitive adhesive layer comprises a drug-retaining layer containing a drug and an acrylic pressure-sensitive adhesive and a skin adhesion layer containing a styrene-isoprene-styrene block copolymer. This preparation can continuously release bisoprolol at a constant concentration. Moreover, it can be easily produced.
Claims10
A transdermal patch for sustained release at a constant concentration comprising a backing and a pressure-sensitive adhesive layer which comprises multiple layers, wherein the pressure-sensitive adhesive layer comprises (i) a drug reservoir layer containing a drug and an acrylic pressure-sensitive adhesive;
- and (ii) a skin adhesion layer containing a styrene-isoprene-styrene block copolymer on the skin contact side, the acrylic pressure-sensitive adhesive is a copolymer comprising (meth)acrylic acid having a carboxyl group as a monomer unit, and the drug is represented by the general formula (I)
- [Chem. 1]
- wherein
- R is selected from the group consisting of 2-isopropoxyethoxymethyl, carbamoylmethyl, and 2-methoxyethyl groups, or a pharmaceutically acceptable salt thereof,
- wherein the drug reservoir layer further comprises a solubilizer and/or a permeation enhancer,
- wherein the skin adhesion layer is laminated on the drug reservoir layer,
- wherein the transdermal patch provides sustained release of the drug at a constant release rate over 24 hours upon application.
Dependencies are inferred from the claim text.