Medical implant sheets useful for tissue regeneration
AssigneeWarsaw Orthopedic, Inc.
InventorWilliam F. McKay
Life of this patent
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Abstract
Described is a medical device in the form of a thin sheet having granules of a calcium-containing, osteoconductive material interconnected by a thin web of polymeric material. The device includes a first face and a second face, wherein at least the first face is populated with proturbances presenting exposed regions of the calcium-containing, osteoconductive material provided by underlying granules. Methods of making and using such devices are also described, as are methods and devices involving the use of very thin polymeric sheets conformed to bone-ingrowth surfaces of load-bearing orthopedic implants.
Claims36
A medical implant device useful for tissue regeneration, said medical implant device comprising:
- granules of a calcium-containing, osteoconductive material, said granules having an average maximum particle diameter greater than 0.05 mm and less than about 5 mm;
- a thin web of biodegradable polymeric material interconnecting said granules and providing said granules and biodegradable polymeric material as an integral, flexible membrane having a first face and a second face, said membrane having an average thickness of about 0.1 mm to 1.5 mm, the thin web of biodegradable polymeric material being a size to wrap around a bone defect and wrap over itself;
- said first face of said flexible membrane having a nonuniform, proturbant surface protruding greater than 0.1 mm above said thin web of biodegradable polymeric material, said nonuniform, proturbant surface populated with a plurality of the granules oriented such that the plurality of the granules form proturbances presenting exposed regions of calcium-containing, osteoconductive material, said exposed regions of calcium-containing, osteoconductive material separated by regions of said biodegradable polymeric material of said web, and
- said second face of said membrane having a nonuniform, proturbant surface protruding greater than 0.1 mm above said thin web of biodegradable polymeric material, said nonuniform, proturbant surface of said second face being populated with a plurality of the granules oriented such that the plurality of the granules form proturbances presenting exposed regions of calcium-containing, osteoconductive material, said exposed regions of calcium-containing, osteoconductive material separated by regions of said biodegradable polymeric material of said web.
Dependencies are inferred from the claim text.