Lingual vestibular dosage-form and delivery system for transmucosal administration of pharmaceutical agents

A lingual vestibular transmucosal pharmaceutical delivery system comprising:

• a pharmaceutical dosage-form;
• and
• a pharmaceutical payload, wherein the pharmaceutical dosage-form comprises the pharmaceutical payload;
• wherein the pharmaceutical dosage-form comprises bilateral flanges connected at the anterior midline, wherein the flanges are shaped to coincide with anatomic tissue curvatures of the lingual vestibule so as to contact mucosal tissues bordering the lingual vestibule, wherein each of the flanges comprises a bottom surface through which the pharmaceutical payload is transmucosally delivered via the mucosal tissues bordering the lingual vestibule, and wherein the bottom surface is non-planar.

A lingual vestibular transmucosal pharmaceutical delivery system comprising:

• a pharmaceutical dosage-form;
• and
• a pharmaceutical payload, wherein the pharmaceutical dosage-form comprises the pharmaceutical payload;
• wherein the pharmaceutical dosage-form comprises bilateral flanges connected at the anterior midline, wherein the flanges are shaped to coincide with anatomic tissue curvatures of the lingual vestibule so as to contact mucosal tissues bordering the lingual vestibule, wherein each of the flanges comprises an outer side surface through which the pharmaceutical payload is transmucosally delivered via the mucosal tissues bordering the lingual vestibule, and wherein the outer side surface is non-planar.

A lingual vestibular transmucosal pharmaceutical delivery system comprising:

• a pharmaceutical dosage-form;
• and
• a pharmaceutical payload, wherein the pharmaceutical dosage-form comprises the pharmaceutical payload;
• wherein the pharmaceutical dosage form bilateral flanges connected at the anterior midline, wherein the flanges are shaped to coincide with anatomic tissue curvatures of the lingual vestibule so as to contact mucosal tissues bordering the lingual vestibule, wherein each of the flanges comprises an inner side surface through which the pharmaceutical payload is transmucosally delivered via the mucosal tissues bordering the lingual vestibule, and wherein the inner side surface is non-planar.

A lingual vestibular transmucosal pharmaceutical delivery system comprising:

• pharmaceutical dosage-form;
• and
• a pharmaceutical payload, wherein the pharmaceutical dosage-form comprises the pharmaceutical payload:
• wherein the pharmaceutical dosage-form comprises bilateral flanges connected at the anterior midline, wherein the flanges are shaped to coincide with anatomic tissue curvatures of the lingual vestibule so as to contact mucosal tissues bordering the lingual vestibule, wherein each of the flanges comprises an upper surface through which the pharmaceutical payload is transmucosally delivered via the mucosal tissues bordering the lingual vestibule, and wherein the upper surface is non-planar.

A lingual vestibular transmucosal pharmaceutical delivery system comprising:

• a pharmaceutical dosage-form;
• and
• a pharmaceutical payload, wherein the pharmaceutical dosage form comprises the pharmaceutical payload;
• wherein the pharmaceutical dosage-form comprises bilateral flanges connected at the anterior midline, wherein the flanges are shaped to coincide with anatomic tissue curvatures of the lingual vestibule so as to contact mucosal tissues bordering the lingual vestibule, wherein each of the flanges comprises bottom, outer side, inner side, and upper surfaces through which the pharmaceutical payload is transmucosally delivered via the mucosal tissues bordering the lingual vestibule, and wherein each of the surfaces is non-planar.