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US 8,524,254 B2Granted
Bioresorbable polymers
AssigneeFerring B.V.
InventorsDonald Magnus Nicolson, Janet Anne Halliday, Jukka Tuominen, Amaia Zurutuza
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Abstract
A bioresorbable polymer is obtained by reacting together (a) a prepolymer comprising co-polymerised units of a caprolactone and poly(alkylene oxide) moieties; (b) a polycaprolactone diol comprising co-polymerised units of a caprolactone and a C2-C6 diol; and (c) a diisocyanate. The polymer may be loaded with a pharmaceutically active agent to produce a drug delivery device.
Claims38
A polymer obtained by reacting together:
- (a) a prepolymer comprising co-polymerised units of a caprolactone and poly(alkylene oxide) moieties;
- (b) a polycaprolactone diol comprising co-polymerised units of a caprolactone and a C2-C6 diol, the C2-C6 diol having a lower molecular weight than the poly(alkylene oxide) of prepolymer (a);
- and
- (c) a diisocyanate;
- wherein the molar ratio of component (a) to component (b) to component (c) is in the range of about 0.15-1.5 to about 1.0 to about 1.0-2.75 and the polymer is a linear polymer.
2 more elements
Dependencies are inferred from the claim text.