Temperature sensitive vaccine strain of Mycoplasma hyopneumoniae and uses thereof
AssigneesBioproperties Pty Ltd., The University of Melbourne
InventorsRima Youil, Youssef Abs El-Osta, Glenn Browning, Phillip Markham
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Abstract
The present invention relates to a Mycoplasma hyopneumoniae vaccine strain comprising a mutation in at least one of the genes listed or as deposited with the National Measurements Institute (Australia) under accession number NM04/41259, which strain is temperature sensitive and attenuated, a vaccine comprising such strains and methods and uses thereof.
Claims19
A vaccine composition comprising an adjuvant together with the Mycoplasma hyopneumoniae strain deposited with the National Measurements Institute, Australia under accession number NM04/41259, which strain is temperature sensitive and attenuated, prepared by subjecting a suitable starting strain of Mycoplasma hyopneumoniae to chemical mutagenesis and selecting a temperature sensitive mutant that remains viable after a serial in vitro passaging, which vaccine in an immunizing amount is capable of eliciting protective immunity against a disease caused by Mycoplasma hyopneumoniae.
A Mycoplasma hyopneumoniae vaccine strain deposited with the National Measurements Institute (Australia) under accession number NM04/41259, which strain is temperature sensitive and attenuated.
Dependencies are inferred from the claim text.