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US 8,524,242 B2Granted
Soluble aggregate, immune tolerance inducer and manufacturing method thereof
AssigneesWako Filter Technology Co., Ltd., Protec Co., Ltd.
InventorsAkira Saito, Akio Kato
Life of this patent
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Abstract
A soluble aggregate of allergen proteins, prepared by heating multiple allergen proteins and aggregating the allergen proteins and thus enclosing the antigen structures causing allergic reactions therein.
Claims2
A method of producing a soluble aggregate of Cry j 1 cedar pollen allergen proteins, comprising:
- heating multiple Cry j 1 cedar pollen allergen proteins, which are dissolved in an acetate buffer solution, at a heating rate of 1° C./min from 40 to 90° C., to thereby aggregate these Cry j 1 cedar pollen allergen proteins and to thus enclose antigen structures causing allergic reactions therein, to obtain a transparent and soluble aggregate without solidification.
A method of producing an immunological tolerance-inducing agent inducing immunological tolerance by oral or transmucosal administration, comprising:
- heating multiple Cry j 1 cedar pollen allergen proteins, which are dissolved in an acetate buffer solution, at a heating rate of 1° C./min from 40 to 90° C., to thereby aggregate these Cry j 1 cedar pollen allergen proteins and to thus enclose antigen structures causing allergic reactions therein, to obtain a transparent soluble aggregate without solidification.
Dependencies are inferred from the claim text.