Back to results
US 8,524,241 B2Granted
Fusion proteins comprising a fragment of Vibrio cholerae exotoxin A
AssigneeThe General Hospital Corporation
InventorsBrian Seed, Jia Liu Wolfe, Chia-Lun Tsai
Life of this patent
Estimating the term…
Abstract
The invention features recombinant exotoxins from Vibrio cholerae are for the therapeutic treatment of a variety of human diseases, particularly diseases characterized by an abundance or excess of undesired cells.
Claims8
A fusion protein comprising a fragment of VCE (Vibrio cholerae exotoxin A), wherein said fragment:
- comprises an amino acid sequence with greater than 90% sequence identity to SEQ ID NO:
- 2,
- has an inactive native targeting domain or lacks a native targeting domain, and
- optionally comprises the native VCE furin cleavage site;
- and wherein said fusion protein comprises:
- (1) cell-membrane translocation activity and (2) a non-native cell targeting moiety.
3 more elements
Dependencies are inferred from the claim text.