Method for treating coronary artery disease using antibody binding human protein tyrosine phosphatase beta(HPTPbeta)
AssigneeAeripo Therapeutics Inc.
InventorsRocco Jamie Rotello, Kevin Gene Peters, Michael Glenn Davis
Life of this patent
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Abstract
Antibodies and antigen binding fragments thereof that bind to human protein tyrosine phosphatase beta (HPTPβ), and uses thereof.
Claims15
A method of treating skeletal muscle or myocardial ischemia, stroke, coronary artery disease, or peripheral vascular disease, comprising administering to the subject an effective amount of an antibody or antigen-binding fragment thereof which binds HPTPbeta and regulates angiogenesis.
A method of enhancing Tie-2 signaling in a subject having skeletal muscle or myocardial ischemia, stroke, coronary artery disease, or peripheral vascular disease, comprising administering to the subject an effective amount of an antibody or antigen-binding fragment thereof which binds HPTPbeta and regulates angiogenesis.
A method for promoting endothelial cell migration in a subject having skeletal muscle or myocardial ischemia, stroke, coronary artery disease, or peripheral vascular disease, comprising administering to the subject an effective amount of an antibody or antigen-binding fragment thereof which binds HPTPbeta and regulates angiogenesis.
A method for promoting endothelial cell survival in a subject having skeletal muscle or myocardial ischemia, stroke, coronary artery disease, or peripheral vascular disease, comprising administering to the subject an effective amount of an antibody or antigen-binding fragment thereof which binds HPTPbeta and regulates angiogenesis.
A method for promoting blood vessel morphogenesis and blood vessel stabilization in a subject having skeletal muscle or myocardial ischemia, stroke, coronary artery disease, or peripheral vascular disease, comprising administering to the subject an effective amount of an antibody or antigen-binding fragment thereof which binds HPTPbeta and regulates angiogenesis.
Dependencies are inferred from the claim text.