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US 8,524,219 B2Granted
Simian subfamily B adenoviruses SAdV-28, -27, -29, -32, -33, and -35 and uses thereof
AssigneeThe Trustees of the University of Pennsylvania
InventorsSoumitra Roy, James M Wilson, Luc H Vandenberghe
Life of this patent
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Abstract
A recombinant vector comprises simian adenovirus 28, simian adenovirus 27, simian adenovirus 32, simian adenovirus 33, and/or simian adenovirus 35 sequences and a heterologous gene under the control of regulatory sequences. A cell line which expresses one or more simian adenovirus-28, -27, -32, -33, or -35 genes is also disclosed. Methods of using the vectors and cell lines are provided.
Claims11
An adenovirus having a capsid comprising a hexon protein of SAdV-28 with the amino acids 1 to 944 of SEQ ID NO:
- 11;
- and a fiber protein of said SAdV-28 with the amino acids 1 to 323 of SEQ ID NO:
- 21, said capsid encapsidating a heterologous nucleic acid comprising a gene operably linked to expression control sequences which direct transcription, translation, and/or expression thereof in a host cell.
Dependencies are inferred from the claim text.