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US 8,524,217 B2Granted
MCP1-Ig fusion variants
AssigneeMerck Sharp & Dohme Corp.
InventorsLeonard G. Presta, Chuan-Chu Chou
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Abstract
The present invention provides, in part, MCP1-Ig fusion polypeptides exhibiting surprisingly beneficial properties as well as methods for treating various diseases (e.g., inflammatory diseases) by administering any of such fusions.
Claims10
An isolated polypeptide comprising an MCP1 polypeptide that comprises the amino acid sequence set forth in SEQ ID NO:
- 17;
- fused to a polypeptide linker, that comprises an amino acid sequence which is a member selected from the group consisting of SEQ ID NOs:
- 1-13;
- fused to a human immunoglobulin gamma-1 polypeptide comprising the immunoglobulin hinge to the immunoglobulin CH3 region that comprises the amino acid sequence set forth in SEQ ID NO:
- 15.
2 more elements
Dependencies are inferred from the claim text.