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US 8,524,215 B2Granted
Absorbable PEG-based hydrogels
AssigneeJanssen Biotech, Inc.
InventorsChee-Youb Won, Helen Cui
Life of this patent
Estimating the term…
Abstract
An absorbable PEG-based hydrogel prepared from a multi-arm-PEG-vinylsulfone having about 3 to about 8 arms and a multi-arm-PEG-R-sulfhydryl having about 3 to about 8 arms; where R is defined as an ester linkage, such as carboxylate ester, lactate ester, and isobutyrate ester have been disclosed. Additionally, sustained release compositions that are prepared from an absorbable PEG-based hydrogel and a protein have been disclosed which provide sustained release of proteins and peptides.
Claims6
A method of sustained release of a protein comprising the steps of:
- providing a sustained release composition comprising, a PEG-based hydrogel comprising, the reaction product of a multi-arm-PEG-vinylsulfone having about 3 to about 8 arms and a multi-arm-PEG-R-sulfhydryl having about 3 to about 8 arms;
- wherein R si an ester linkage selected from the group consisting of carboxylate ester, lactate ester, and isobutyrate ester;
- and a protein, implanting the sustained release composition, and releasing the protein from the composition for up to about 180 days.
Dependencies are inferred from the claim text.