Plant-derived elastin binding protein ligands and methods of using the same
AssigneesHuman Matrix Sciences, LLC, The Hospital for Sick Children
InventorsFelipe Jimenez, Thomas Mitts, Aleksander Hinek
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Abstract
The present invention describes novel plant derived elastin-like peptides and peptidomimetics that may serve as functional ligands for elastin receptors and stimulate elastogenesis. The novel plant derived peptides provide an alternative (non-animal derived) source of GXXPG (SEQ ID NO. 2) containing peptides. The present invention also describes therapeutic compositions containing novel plant derived peptides or peptidomimetics useful in stimulating elastogenensis and capillary dilatation. The therapeutic compositions of the present invention that comprise novel plant derived peptides or peptidomimetics may be combined with other therapeutic agents.
Claims14
A method of stimulating elastogenesis comprising administering a therapeutically effective amount of a composition comprising a synthetic sextapeptide having a sequence X1-X2-X3-X4-X5-X6 (SEQ ID NO. 3), wherein:
- X1 is V or I;
- X2 is G;
- X3 is A or L;
- X4 is M or S;
- X5 is P;
- and
- X6 is G;
- and
- wherein the administering includes at least one of topical application and application via a transdermal patch.
A method of stimulating elastogenesis comprising administering a therapeutically effective amount of a composition comprising a synthetic linked sextapeptide having a sequence X1-X2-X3-X4-X5-X6,-X7-X1-X2-X3-X4-X5-X6 (SEQ ID NO. 16) wherein:
- X7 is a linking moiety;
- X1 is independently selected from V and I;
- X2 is G;
- X3 is independently selected from A and L;
- X4 is independently selected from M and S;
- X5 is P;
- and
- X6 is G.
Dependencies are inferred from the claim text.