Non-invasive diagnostic imaging technology for mitochondria using radiolabeled lipophilic salts
AssigneeThe Johns Hopkins University
InventorsIgal Madar, Hayden T. Ravert, Robert Francis Dannals, Ursula A. Scheffel, James J. Frost
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Abstract
The invention provides lipophilic salts, particularly, lipophilic salts comprising a pharmaceutically acceptable anion and at least one phosphonium or ammonium cation. In certain embodiments, the cation is labeled with one or more radioisotopes. The lipophilic salts of the invention exhibit an affinity for dysfunctional mitochondria, and are useful for the imaging of cardiovascular diseases and disorders. The invention also provides pharmaceutical compositions and methods of using the lipophilic salts.
Claims13
A method of imaging cardiac infarction, cardiac perfusion, heart failure, cardiomyopathy or ischemia comprising:
- providing a radiolabeled salt comprising at least one pharmaceutically acceptable anion and 18F-4-fluorobenzyl-triphenylphosphonium ion;
- contacting cells or tissues in a subject with the radiolabeled salt;
- and
- making a radiographic image.
Dependencies are inferred from the claim text.