Multi-modal drug delivery system
AssigneeLaboratoire Naturel Paris, LLC
InventorJ. Chris Castel
Life of this patent
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Abstract
A device for the transdermal delivery of a therapeutic agent at a treatment site comprising a housing containing: a mechanical vibration element; a light source; a heating and/or cooling element; a power source for powering said mechanical vibrational element, light source, and heating element; and an electronic control module.
Claims91
A device for the transdermal delivery of a therapeutic agent to the skin at a treatment site comprising a housing containing:
- a mechanical vibration element, wherein said mechanical vibration element is selected from the group consisting of (a) a mechanical vibration element which produces mechanical energy having a frequency of about 15 kHz to 100 kHz;
- (b) a mechanical vibration element which produces mechanical energy having a frequency of about 100 kHz to 5 MHz modulated with mechanical energy having a frequency of about 15 kHz to 100 kHz;
- and (c) a mechanical vibration element which produces mechanical energy having a frequency of about 10 Hz to 1000 Hz modulated with mechanical energy having a frequency of about 15 kHz to 100 kHz;
- a light source;
- a heating and/or cooling element;
- a power source for powering said mechanical vibrational element, light source, and heating and/or cooling element;
- and
- an electronic control module for controlling said mechanical vibrational element, light source, and heating and/or cooling element.
A method for transdermally delivering a therapeutic agent to a patient's treatment site on the skin comprising:
- (a) decreasing the temperature of the treatment site by cooling the treatment site;
- (b) applying mechanical energy the treatment site, said mechanical energy having a frequency selected from the group consisting of (i) a frequency of about 15 kHz to 100 kHz;
- (ii) a frequency of about 100 kHz to 5 MHz modulated with mechanical energy having a frequency of about 15 kHz to 100 kHz;
- and (iii) a frequency of about 10 Hz to 1000 Hz modulated with mechanical energy having a frequency of about 15 kHz to 100 kHz;
- (c) applying light energy to said treatment site;
- and
- (d) applying a composition comprising a therapeutically effective amount of said therapeutic agent.
A method for transdermally delivering a therapeutic agent to a patient's treatment site on the skin comprising:
- (a) increasing the temperature of the treatment site by heating the treatment site by about 0.5 to 2° C.;
- (b) applying mechanical energy the treatment site, said mechanical energy having a frequency selected from the group consisting of (i) a frequency of about 15 kHz to 100 kHz;
- (ii) a frequency of about 100 kHz to 5 MHz modulated with mechanical energy having a frequency of about 15 kHz to 100 kHz;
- and (iii) having a frequency of about 10 Hz to 1000 Hz modulated with mechanical energy having a frequency of about 15 kHz to 100 kHz;
- (c) applying light energy to said treatment site;
- and
- (d) applying a composition comprising a therapeutically effective amount of said therapeutic agent to the treatment site.
A method for transdermally delivering a therapeutic agent to a patient's treatment site on the skin comprising:
- (a) increasing the temperature of the treatment site by heating the treatment site by about 2 to 4° C.;
- (b) applying mechanical energy the treatment site, said mechanical energy having a frequency selected from the group consisting of (i) a frequency of about 15 kHz to 100 kHz;
- (ii) a frequency of about 100 kHz to 5 MHz modulated with mechanical energy having a frequency of about 15 kHz to 100 kHz;
- and (iii) a frequency of about 10 Hz to 1000 Hz modulated with mechanical energy having a frequency of about 15 kHz to 100 kHz;
- (c) applying light energy to said treatment site;
- and
- (d) applying a composition comprising a therapeutically effective amount of said therapeutic agent to the treatment site.
Dependencies are inferred from the claim text.