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US 8,513,299 B2Granted
Methods of using low-dose doxepin for the improvement of sleep
AssigneesPernix Sleep, Inc., ProCom One, Inc.
InventorsRoberta L. Rogowski, Susan E. Dubé, Philip Jochelson
Life of this patent
Estimating the term…
Abstract
Methods of preventing early awakenings, and improving sleep efficiency in hours 7 and 8 of a period of sleep, by administration of low doses of doxepin (e.g., 1-6 mg).
Claims22
A method for reducing or preventing early awakenings in a patient in need thereof, comprising:
- identifying a patient having a sleep disorder in which, for a given 8 hour period of desired sleep, the patient experiences a sleep period that terminates during the final 60 minutes of said period;
- and
- providing to the patient doxepin or a pharmaceutically acceptable salt thereof in a dosage between about 0.5 and 6 mg that is effective to lengthen the sleep period.
A method for decreasing fragmented sleep in the 8th hour of a sleep period for a patient, comprising:
- identifying a patient suffering from fragmented sleep during the 8th hour of a sleep period;
- and
- providing to the patient doxepin or a pharmaceutically acceptable salt thereof in a dosage between about 0.5 mg and 6 mg.
A method for reducing early awakenings in a patient in need thereof, comprising:
- identifying a patient having a sleep disorder in which, for a given 8 hour period of desired sleep, the patient experiences a sleep period that terminates during the final 60 minutes of said period;
- and
- providing to the patient doxepin or a pharmaceutically acceptable salt thereof in a dosage between about 0.5 and 6 mg.
Dependencies are inferred from the claim text.