Biopolymer system for tissue sealing
AssigneeEndomedix, Inc.
InventorsWeiliam Chen, John M. Abrahams
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Abstract
A tissue sealant for use in surgical and medical procedures for sealing the tissues of a living mammal is provided. The tissue sealant comprises a hydrogel which is formed by gelation of a premix disposed on the tissue to be sealed. The premix comprises alkylated chitosan or a gelatin, and a polybasic carboxylic acid or an oxidized polysaccharide, in an aqueous medium. The premix can also include a dehydrating reagent, a carboxyl activating reagent, or both. A specific use of the tissue sealant is in the repair of the dura mater after brain surgery to prevent leakage of cerebrospinal fluid. The tissue sealant may include a therapeutic or protective agent such as an antibiotic or an anti-inflammatory drug.
Claims21
A method of sealing a disrupted biological tissue in need thereof in a living mammal, the method comprising applying to the disrupted biological tissue a biocompatible, biodegradable composition produced by mixing a first solution comprising an acrylated chitosan with a second solution comprising oxidized dextran to produce a mixture comprising from about 1% to about 10% by weight of the acrylated chitosan, wherein the acrylated chitosan has a degree of substitution of a chitosan backbone with acrylate groups in the range of from about 0.25 to about 0.5,
- such that, when the mixture is applied to the disrupted biological tissue, the mixture forms a hydrogel within a minute after mixing thereby sealing the biological tissue.
Dependencies are inferred from the claim text.