Electrospun calcium phosphate nanofibers
AssigneeCornell Research Foundations, Inc.
InventorsJian Tan, Yong L. Joo
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Abstract
Calcium-phosphate nanofiber matrices comprising randomly dispersed crystalline calcium-phosphate nanofibers are provided. The nanofibers are synthesized using sol-gel methods combined with electrospinning. The nanofibers may be hollow, solid or may comprise a calcium-phosphate shell surrounding a polymer containing inner core to which biologically functional additives may be added. The nanofiber matrices may be used to culture bone and dental cells, and as implants to treat bone, dental or periodontal diseases and defects.
Claims85
A nanofiber comprising calcium phosphate, wherein the calcium phosphate comprises a Ca2+ ion and at least one phosphate ion having one or more Ca—O—P linkages selected from the group consisting of orthophosphate (PO2−) ions, metaphosphate (PO43−) ions, and pryophosphate ions (P2O74−), and optionally hydrogen or hydroxide ions, wherein the tensile strength of said nanofiber is between 25.0 and 1,000.0 MPa, wherein the nanofiber is electrospun nanofiber, and wherein the maximum distance between any two points on the outer surface of the nanofiber when seen in a cross-section to the longitudinal axis of the fiber is between 10.0 nm to 2.0 microns.
A nanofiber consisting essentially of calcium phosphate, wherein the calcium phosphate comprises a Ca2+ ion and at least one phosphate ion having one or more Ca—O—P linkages selected from the group consisting of orthophosphate (PO2−) ions, metaphosphate (PO43−) ions, and pryophosphate ions (P2O74−), and optionally hydrogen or hydroxide ions, wherein the tensile strength of said nanofiber is between 25.0 and 1,000.0 MPa, wherein the nanofiber is electrospun nanofiber, and wherein the maximum distance between any two points on the outer surface of the nanofiber when seen in a cross-section to the longitudinal axis of the fiber is between 10.0 nm to 2.0 microns.
Dependencies are inferred from the claim text.