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US 8,511,140 B2Granted
Baseline modeling in chromatography
AssigneeWaters Technologies Corporation
InventorsMarc V. Gorenstein, Anthony C. Gilby
Life of this patent
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Abstract
An apparatus and a method of chemical analysis entail acquiring a chromatogram, median filtering the chromatogram to produce a model baseline, smoothing the model baseline to reduce noise, and subtracting the smoothed model baseline from the acquired chromatogram to produce a modified chromatogram having a substantially flat baseline.
Claims21
A method of chemical analysis, comprising:
- acquiring a chromatogram associated with data points that each have a value of retention time and at least one value of magnitude;
- compressing the acquired chromatogram;
- removing at least one chromatographic peak from the compressed chromatogram by median filtering the data points to provide a model baseline;
- smoothing the model baseline to reduce a noise component of the model baseline;
- decompressing the smoothed model baseline;
- and
- subtracting the decompressed smoothed model baseline from the acquired chromatogram to produce a modified chromatogram having the at least one chromatographic peak and a substantially flat baseline.
4 more elements
An apparatus for chemical processing, comprising:
- a chromatography module comprising a detector comprising a light-guided flow cell;
- and
- a control unit, in communication with the detector, comprising at least one processor and at least one memory comprising a plurality of instructions stored thereon for:
- acquiring a chromatogram associated with data points that each have a value of retention time and at least one value of magnitude derived from the detector,
- compressing the acquired chromatogram,
- removing at least one chromatographic peak from the compressed chromatogram by median filtering the data points to provide a model baseline,
- smoothing the model baseline to reduce a noise component of the model baseline,
- decompressing the smoothed model baseline, and
- subtracting the decompressed smoothed model baseline from the acquired chromatogram to produce a modified chromatogram having the at least one chromatographic peak and a substantially flat baseline.
6 more elements
A non-transitory computer readable medium comprising code stored thereon for chemical analysis, the non-transitory computer readable medium comprising code for:
- acquiring a chromatogram associated with data points that each have a value of retention time and at least one value of magnitude;
- compressing the acquired chromatogram;
- removing at least one chromatographic peak from the compressed chromatogram by median filtering the data points to provide a model baseline;
- smoothing the model baseline to reduce a noise component of the model baseline;
- decompressing the smoothed model baseline;
- and
- subtracting the decompressed smoothed model baseline from the acquired chromatogram to produce a modified chromatogram having the at least one chromatographic peak and a substantially flat baseline.
4 more elements
Dependencies are inferred from the claim text.