Apparatus and method for widefield functional imaging (WiFI) using integrated structured illumination and laser speckle imaging
AssigneeThe Regents of the University of California
InventorsAnthony J. Durkin, David Cuccia, Bruce J. Tromberg, Amaan Mazhar, Bernard Choi
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Abstract
An apparatus for wide-field functional imaging (WiFI) of tissue includes a spatially modulated reflectance/fluorescence imaging (SI) device capable of quantitative subsurface imaging across spatial scales, and a laser speckle imaging (LSI) device capable of quantitative subsurface imaging across spatial scales using integrated with the (SI) device. The SI device and LSI device are capable of independently providing quantitative measurement of tissue functional status.
Claims9
A method for imaging of mean particle motion of a particle moving in a turbid medium at each point in a three dimensional wide field of view of the turbid medium using an apparatus for providing structured illumination and for providing coherent illumination comprising:
- imaging the particle motion in the turbid medium using the apparatus for providing structured illumination imaging using different illumination spatial frequencies of the turbid medium by the apparatus to derive static optical properties of the turbid medium;
- imaging the particle motion in the turbid medium using the apparatus for providing temporally coherent illumination imaging to derive dynamic motion of the particle in the turbid medium;
- and
- using a computer to generate an estimate of particle motion at each point using a correlation function model for particle motion in terms of dynamic scattering as measured by a time correlation technique including speckle contrast indicative of speckle blurring.
An apparatus for imaging of mean particle motion in a turbid medium at each point in a wide field of view of a turbid medium comprising:
- means for performing both structured illumination imaging using speckle laser illumination in combination with laser speckle imaging to simultaneously derive optical properties and speckle contrast at different spatial frequencies of the turbid medium;
- and
- means for generating an estimate of particle motion at each point using a correlation function model for particle motion in terms of dynamic scattering as measured in speckle contrast.
Dependencies are inferred from the claim text.