US 8,507,734 B2 · Pharmaceutical compositions comprising monoterpenes

Abstract

The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

Claims19

Dependent claims

A process for purifying (S)-perillyl alcohol comprising the steps of:

(a) derivatizing a mixture comprising (S)-perillyl alcohol to form a perillyl alcohol derivative, wherein the perillyl alcohol derivative is a benzoate ester and has at least one property that allows it to be separated from the mixture;
(b) separating the perillyl alcohol derivative from the mixture using the property for separation;
(c) releasing the (S)-perillyl alcohol from the perillyl alcohol derivative from step (b);
and,
(d) isolating the (S)-perillyl alcohol from step (c),
wherein the (S)-perillyl alcohol has a purity of greater than 98.5% (w/w).

3 more elements

Dependencies are inferred from the claim text.

Pharmaceutical compositions comprising monoterpenes

Life of this patent

Pharmaceutical compositions comprising monoterpenes

Life of this patent

Abstract

Claims19