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US 8,507,724 B2Granted
Compounds for use in the treatment of pain
AssigneeUniversity of Dundee
InventorsMartin Leuwer, Paul O'Neill, Neil Berry, Gertrud Haeseler
Life of this patent
Estimating the term…
Abstract
The present invention concerns compounds derived from the anaethetic propofol. The compounds may be useful in the treatment of pain, particularly, but not exclusively, chronic pain and central pain sensitisation.
Claims22
A compound of formula (III)
- wherein R9, R10, R11, R12 and R13 are each separately selected from the group consisting of hydrogen, halogen, halo-substituted or unsubstituted C1-C4 alkyl, halo-substituted or unsubstituted C1-C4 alkoxy, substituted or unsubstituted amine, substituted or unsubstituted amide, substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl;
- or a salt thereof.
A pharmaceutical composition comprising a therapeutically effective amount of a compound of formula (III)
- wherein R9, R10, R11, R12 and R13 are each separately selected from the group consisting of hydrogen, halogen, halo-substituted or unsubstituted C1-C4 alkyl, halo-substituted or unsubstituted C1-C4 alkoxy, substituted or unsubstituted amine, substituted or unsubstituted amide, substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl;
- or a salt thereof;
- and a pharmaceutically acceptable vehicle.
A method of treating pain, said method comprising administering to a subject in having pain an effective amount of a compound of formula (III)
- wherein R9, R10, R11, R12 and R13 are each separately selected from the group consisting of hydrogen, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted amine, substituted or unsubstituted amide, substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl;
- or a salt thereof.
Dependencies are inferred from the claim text.