Method for producing β-aminocarbonyl compound
AssigneeNational University Corporation Nagoya University
InventorsKazuaki Ishihara, Manabu Hatano, Takahiro Horibe
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Abstract
An optically active β-aminocarbonyl compound is obtained by a Mannich reaction between an aldimine in which: nitrogen is protected and a malonic acid diester, in the presence of optically active BINOL and dialkyl magnesium (in which two alkyl groups are the same or different) in an amount 1 to 2 molar times the amount of the BINOL.
Claims5
A method for producing a β-aminocarbonyl compound comprising carrying out a Mannich reaction between an aldimine in which nitrogen is protected and a malonic acid diester, in the presence of optically active BINOL and dialkyl magnesium in which two alkyl groups are the same or different in an amount 1 to 2 molar times the amount of the BINOL, to obtain an optically active β-aminocarbonl compound.
Dependencies are inferred from the claim text.