7-membered ring compound and method of production and pharmaceutical application thereof

A compound, or its salt or a solvate thereof, having the formula (Va):

• wherein W′ indicates a phenyl,
• wherein the NH2—CH(R18)— group and R19O—C(═O)— group of W′ are 1,4 substituted;
• and
• wherein the groups (1) and (2) of W′ may optionally be substituted with 1 to 4 groups selected from the group consisting of (i) a halogen atom, (ii) nitro, (iii) cyano, (iv) C1 to C6 alkyl which may optionally be substituted with 1 to 3 groups selected from a halogen atom, amino, C1 to C6 alkoxycarbonyl, C1 to C6 alkoxycarbonylamino, and carboxyl, (v) C2 to C6 alkenyl which may optionally be substituted with 1 to 3 halogen atoms, (vi) C2 to C6 alkynyl which may optionally be substituted with 1 to 3 halogen atoms, (vii) C3 to C6 cycloalkyl, (viii) hydroxyl, (ix) C1 to C6 alkoxy which may optionally be substituted with 1 to 3 groups selected from a halogen atom, hydroxyl, C1 to C6 alkoxy, amino, and mono- or di-C1 to C6 alkylamino, (x) C1 to C5 alkylenedioxy, (xi) C1 to C6 alkylthio which may optionally be substituted with 1 to 3 groups selected from a halogen atom, hydroxyl, C1 to C6 alkoxy, amino, and mono- or di-C1 to C6 alkylamino, (xii) amino, (xiii) mono-C1 to C6 alkylamino, (xiv) di-C1 to C6 alkylamino, (xv) 5- to 6-membered cyclic amino, (xvi) C1 to C6 alkylcarbonyl, (xvii) carboxyl, (xviii) C1 to C6 alkoxycarbonyl, (xix) C7 to C16 aralkyloxycarbonyl, (xx) carbamoyl, (xxi) mono-C1 to C6 alkylcarbamoyl which may optionally be substituted with 1 to 3 groups selected from a halogen atom, hydroxyl, carboxyl, C1 to C6 alkoxy, amino, and mono- or di-C1 to C6 alkylamino, (xxii) di-C1 to C6 alkylcarbamoyl which may optionally be substituted with hydroxyl, (xxiii) 5 to 6-membered cyclic aminocarbonyl which may optionally be substituted with C1 to C6 alkoxycarbonyl, (xxiv) C6 to C10 arylcarbamoyl, (xxv) C1 to C10 heteroarylcarbamoyl, (xxvi) C7 to C16 aralkylcarbamoyl, (xxvii) C1 to C10 heteroaryl-C1 to C6 alkylcarbamoyl, (xxviii) N—C1 to C6 alkyl-N—C6 to C12 arylcarbamoyl, (xxix) C3 to C6 cycloalkylcarbamoyl, (xxx) sulfo, (xxxi) C1 to C6 alkylsulfonyl, (xxxii) C1 to C6 alkylsulfonylamino, (xxxiii) C6 to C12 arylsulfonylamino which may be substituted with C1 to C6 alkyl, (xxxiv) C1 to C10 heteroarylsulfonylamino, (xxxv) C1 to C6 alkoxycarbonylamino, (xxxvi) C1 to C6 alkylcarbonylamino, (xxxvii) mono- or di-C1 to C6 alkylaminocarbonylamino, (xxxviii) C6 to C12 aryl, (xxxix) C1 to C10 heteroaryl, (xl) C6 to C10 aryloxy, (xli) C1 to C10 heteroaryloxy, (xlii) C7 to C16 aralkyloxy, (xliii) C1 to C10 heteroaryl-C1 to C6 alkyloxy, (xliv) aminosulfonyl, (xlv) mono- or di-C1 to C6 alkylaminosulfonyl, (xlvi) C7 to C16 aralkyloxycarbamoyl, and (xlvii) C1 to C10 heteroaryl-C1 to C6 alkyloxycarbamoyl,
• R18 indicates a C2 to C4 alkyl group which may optionally be substituted with 1 to 3 halogen atoms, and R19 indicates a hydrogen atom, C1 to C6 alkyl group which may optionally be substituted with 1 to 3 halogen atoms, or C7 to C16 aralkyl group which may optionally be substituted with 1 to 3 halogen atoms.